9-Piperazine Levofloxacin IMpurity

9-Piperazine Levofloxacin IMpurity - Names and Identifiers

Name	(S)-10-fluoro-3-methyl-9-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid
Synonyms	Levofloxacin Impurity M Levofloxacin Impurity G01 9-Piperazino Levofloxacin Levofloxacin 9-Piperazinyl Isomer 9-Piperazino Levofloxacin IMpurity 9-Piperazine Levofloxacin IMpurity (S)-10-fluoro-3-methyl-9-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid
CAS	178912-62-4

9-Piperazine Levofloxacin IMpurity - Physico-chemical Properties

Molecular Formula	C18H20FN3O4
Molar Mass	361.37
Density	1.48±0.1 g/cm3(Predicted)
Boling Point	588.1±50.0 °C(Predicted)
pKa	5.28±0.40(Predicted)
Storage Condition	-20℃

9-Piperazine Levofloxacin IMpurity - Reference Information

Overview

fluoroquinolones are characterized by broad-spectrum, high efficiency and low toxicity, great success has been achieved in clinical anti-infection treatment. Among them, ofloxacin, levofloxacin and Levofloxacin Hydrochloride were the excellent representatives. Levofloxacin developed by Japan's first three co-Pharmaceutical Co., Ltd. is an excellent variety with a wide market share, and its chemical name is (-)-(S)-3-methyl-9-fluoro-2, 3-dihydro-10-(4-methyl-1-piperazinyl)-7-oxo-7h-pyrido [1,2,3-de]-[1,4] benzoxazine-6-carboxylic acid), as a hemihydrate. The synthesis process of levofloxacin has been very mature, and there are many reports. The last step is to synthesize levofloxacin by condensation reaction. The above preparation process may produce site isomeric impurity (1), chemical name:(S)-(-)-10-fluorine -2, 3-dihydro-3-methyl-9-(4-methyl-1-piperazinyl)-7-oxo-7h-pyrido [1,2,3-de]-[1,4] benzoxazine-6-carboxylic acid, abbreviated as 9-levofloxacin piperazine impurity.

Last Update：2024-04-09 21:54:55